Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4354580 | Trends in Neurosciences | 2009 | 12 Pages |
Abstract
Schizophrenia is a complex mental disorder that is still characterized by its symptoms rather than by biological markers because we have only a limited knowledge of its underlying molecular basis. In the past two decades, however, technical advances in genetics and brain imaging have provided new insights into the biology of the disease. Based on these advances we are now in a position to develop animal models that can be used to test specific hypotheses of the disease and explore mechanisms of pathogenesis. Here, we consider some of the insights that have emerged from studying in mice the relationship between defined genetic and molecular alterations and the cognitive endophenotypes of schizophrenia.
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Authors
Christoph Kellendonk, Eleanor H. Simpson, Eric R. Kandel,