| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4355362 | Hearing Research | 2012 | 15 Pages |
Abstract
⺠Adult cochleas lack most neurotrophins while corresponding receptors are all present. ⺠All four neurotrophins are similarly effective in preserving spiral ganglion cells. ⺠Presence of all neurotrophin receptors explains similar preservative effect. ⺠Preservative effect continues after cessation of temporary neurotrophic treatment. ⺠An autocrine mechanism may explain continued preservative effect.
Keywords
p75NTRNT-4/5SGCNTFCNTFNT-3FGFECAPNGFSNHLGDNFNTRBDNFeABRamyotrophic lateral sclerosisAlzheimer's diseaseALSParkinson's diseasesubstantia nigraSpiral ganglion cellNeurotrophic factornerve growth factorfibroblast growth factorGlial cell line-derived neurotrophic factorBrain-derived neurotrophic factorciliary neurotrophic factorneurotrophin-4/5neurotrophin-3Electrically evoked auditory brainstem responseelectrically evoked compound action potentialCochlear implantsensorineural hearing lossp75 neurotrophin receptorNeurotrophin receptor
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Authors
Dyan Ramekers, Huib Versnel, Wilko Grolman, Sjaak F.L. Klis,