| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4355433 | Hearing Research | 2011 | 10 Pages |
Abstract
⺠Extra- and intracellular gentamicin (1 mM) decreases the Ca2+ current, ICa, of hair cells of the frog semicircular canals. ⺠The effect of gentamicin is fast and apparently operates by reducing the number of available Ca2+ channels. ⺠Reduction of ICa decreases IKCa, which plays a major role in controlling the hair cell membrane potential. ⺠Other potassium currents, such as IKV and IA, are unaffected by the treatment. ⺠Functional impairment develops much earlier than the biochemical events leading to cell apoptosis.
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Authors
Marta Martini, Rita Canella, Ivo Prigioni, Giancarlo Russo, Elisa Tavazzani, Riccardo Fesce, Maria Lisa Rossi,