Short-term synaptic plasticity and intensity coding

Alterations in synaptic strength over short time scales, termed short-term synaptic plasticity, can gate the flow of information through neural circuits. Different information can be extracted from the same presynaptic spike train depending on the activity- and time-dependent properties of the plasticity at a given synapse. The parallel processing in the brain stem auditory pathways provides an excellent model system for investigating the functional implications of short-term plasticity in neural coding. We review recent evidence that short-term plasticity differs in different pathways with a special emphasis on the ‘intensity’ pathway. While short-term depression dominates the ‘timing’ pathway, the intensity pathway is characterized by a balance of short-term depression and facilitation that allows linear transmission of rate-coded intensity information. Target-specific regulation of presynaptic plasticity mechanisms underlies the differential expression of depression and facilitation. The potential contribution of short-term plasticity to different aspects of ‘intensity’-related information processing, such as interaural level/intensity difference coding, amplitude modulation coding, and intensity-dependent gain control coding, is discussed.

► Short-term synaptic plasticity differs in auditory timing and intensity pathways. ► Balanced synapses enhance encoding of intensity information. ► Desensitization and facilitation contribute to difference in plasticity. ► May play a role in interaural level difference and amplitude modulation coding and inhibitory gain feedback.