Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4355612 | Hearing Research | 2010 | 6 Pages |
Abstract
Previous studies in animals and humans have shown that, in some cases at least, anti-epileptic drugs can reduce the severity of tinnitus. Given that cannabinoid receptor agonists have been shown to exert anti-epileptic effects in some circumstances, we investigated whether two synthetic CB1/CB2 receptor agonists, WIN55,212-2, and CP55,940, could inhibit the behavioural manifestations of salicylate-induced tinnitus in rats in a conditioned suppression task. We found that neither WIN55,212-2 (3.0Â mg/kg s.c) nor CP55,940 (0.1 or 0.3Â mg/kg s.c), significantly reduced conditioned behaviour associated with tinnitus. However, both 3Â mg/kg WIN55,212-2 and 0.3Â mg/kg CP55,940 did significantly increase tinnitus-related behaviour compared to the vehicle control groups. These results suggest that cannabinoid receptor agonists may not be useful in the treatment of salicylate-induced tinnitus and that at certain doses, they could actually exacerbate the condition.
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Sensory Systems
Authors
Yiwen Zheng, Lucy Stiles, Emma Hamilton, Paul F. Smith, Cynthia L. Darlington,