Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4356127 | Hearing Research | 2008 | 10 Pages |
Abstract
Many studies have been carried out in order to demonstrate the persistence of endogenous progenitors. The present review is first focused on the occurrence of spontaneous supernumerary hair cells and on nestin positive precursors found in the organ of Corti. A second approach to regenerating hair cells would be to find genes essential for their differentiation. This review will also focus on critical genes for embryonic hair cell formation such as the cell cycle related proteins, the Atoh1 gene and the Notch signaling pathway. Understanding mechanisms that underlie hair cell production is an essential prerequisite to defining therapeutic strategies to regenerate hair cells in the mature inner ear.
Keywords
CDKlesser epithelial ridgeCDKIbHLHFGF2PRBGFPEGFbasic helix-loop-helixRegenerationCochleaLERGERDIVDevelopmentday in vitroembryonic daypostnatal daygreater epithelial ridgesupporting cellhair cellepidermal growth factorfibroblast growth factor 2cdk inhibitorsretinoblastoma proteingreen fluorescent proteincyclin-dependent kinaseInner ear
Related Topics
Life Sciences
Neuroscience
Sensory Systems
Authors
Ingrid Breuskin, Morgan Bodson, Nicolas Thelen, Marc Thiry, Laurent Nguyen, Shibeshih Belachew, Philippe P. Lefebvre, Brigitte Malgrange,