Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4358346 | Research in Microbiology | 2016 | 7 Pages |
Abstract
The major virulence trait of Mycobacterium tuberculosis is its ability to enter a latent state in the face of robust host immunity. Clues to the molecular basis of latency can emerge from understanding the mechanism of cell division, beginning with identification of proteins involved in this process. Using complementation of Escherichia coli mutants, we functionally annotated M. tuberculosis and Mycobacterium smegmatis homologs of divisome proteins FtsW and AmiC. Our results demonstrate that E. coli can be used as a surrogate model to discover mycobacterial cell division genes, and should prove invaluable in delineating the mechanisms of this fundamental process in mycobacteria.
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Authors
Sujata S. Gaiwala Sharma, Vimal Kishore, Tirumalai R. Raghunand,