| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4360205 | Trends in Immunology | 2010 | 7 Pages |
Abstract
The progressive maturation of T cells is accompanied by their migration through the thymus, with each selection stage occurring in distinct microenvironments. Many specialized receptor–ligand pairs have been defined that drive T cell differentiation, but our understanding of the complex relationship between T cells and the thymic stroma is incomplete. Recent reports have identified a role for the chemokine stromal cell-derived factor 1α and its receptor CXC chemokine receptor 4 in β-selection. This review explores these findings in detail.
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Authors
Michelle L. Janas, Martin Turner,