| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4360396 | Trends in Immunology | 2007 | 4 Pages |
Abstract
The gastrointestinal immune system consists of immune cells in organized gut-associated lymphoreticular tissues (GALT) and diffuse lamina propria, which give rise to mucosal secretory IgA antibody responses. A recent study showed that the retinoic acid produced by GALT dendritic cells (DCs) imprints B cells for gut homing. Surprisingly, GALT DCs, together with interleukin-5 (IL-5) and IL-6, also provided a milieu for both B cell switching to IgA and IgA synthesis.
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Authors
Jerry R. McGhee, Jun Kunisawa, Hiroshi Kiyono,