| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4360701 | Trends in Immunology | 2006 | 4 Pages |
Abstract
Disturbances in crosstalk between the immune system and the sympathetic nervous system (SNS) can contribute to the pathogenesis of Th1-mediated autoimmunity. Recent studies indicate that neuropeptide Y (NPY) has a major role in the regulation of Th1 responses. The precise role of NPY has been an enigma, but a recent study provides a breakthrough, demonstrating that NPY has a bimodal role as a negative regulator of T cells and an activator of antigen-presenting cell function.
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Authors
Thomas Prod'homme, Martin S. Weber, Lawrence Steinman, Scott S. Zamvil,