Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4365952 | International Biodeterioration & Biodegradation | 2008 | 6 Pages |
Abstract
Bacillus megaterium was used in biotransformation studies to test the influence of several barbiturates towards the recently observed N-dealkylation and arylic hydroxylation of N,N-diethylaniline. Certain barbiturates (phenobarbital and amobarbital) induced increased enzyme activity in whole-cell incubations with B. megaterium resulting in an increasing amount of N-deethylated and hydroxylated arylic (ortho- and para-hydroxylation) products, whereas ortho-hydroxylation was slightly favored. Phenobarbital did not show any effects towards hydroxylation activity, but N-dealkylation activity was highly induced. Finally, metyrapone highly reduced hydroxylation and N-dealkylation activity.
Related Topics
Life Sciences
Environmental Science
Environmental Science (General)
Authors
Marcus Taupp, Frank Heckel, Dag Harmsen, Peter Schreier,