| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4370969 | Experimental Parasitology | 2016 | 8 Pages |
•Eco-friendly green synthesis of silver nanoparticles (AgNP) was performed using Anisomeles indica leaf extract.•Green synthesized AgNP were characterized by UV–vis, FTIR, SEM, EDX, TEM and XRD.•Potent larvicidal activity was noticed against filariasis, malaria and dengue mosquito vectors.•LC50 value ranged from 31.56 to 38.08 μg/mL.
Mosquitoes (Diptera: Culicidae) represent a key threat for millions of people worldwide, since they act as vectors for devastating parasites and pathogens. In this scenario, eco-friendly control tools against mosquito vectors are a priority. Green synthesis of silver nanoparticles (AgNP) using a cheap, aqueous leaf extract of Anisomeles indica by reduction of Ag+ ions from silver nitrate solution has been investigated. Bio-reduced AgNP were characterized by UV–visible spectrophotometry, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDX) and X-ray diffraction analysis (XRD). The acute toxicity of A. indica leaf extract and biosynthesized AgNP was evaluated against larvae of the malaria vector Anopheles subpictus, the dengue vector Aedes albopictus and the Japanese encephalitis vector Culex tritaeniorhynchus. Both the A. indica leaf extract and AgNP showed dose dependent larvicidal effect against all tested mosquito species. Compared to the leaf aqueous extract, biosynthesized AgNP showed higher toxicity against An. subpictus, Ae. albopictus, and Cx. tritaeniorhynchus with LC50 values of 31.56, 35.21 and 38.08 μg/mL, respectively. Overall, this study firstly shed light on the mosquitocidal potential of A. indica, a potential bioresource for rapid, cheap and effective AgNP synthesis.
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