| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4371282 | Experimental Parasitology | 2011 | 6 Pages |
The effect of 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1) isolated from Solanum nudum Dunal (a Solanaceae traditionally used for treating fever in Colombia) on Plasmodium falciparum erythrocyte stages and its in vitro antiplasmodial activity when combined with the following conventional drugs was studied: chloroquine (CQ), amodiaquine (AQ), desethylamodiaquine (desethyl-AQ), quinine (QN), artemisinin (AR), atovaquone (ATV) and quinine (QN). It was found that SN-1 targeted trophozoites and had a synergistic effect when combined with CQ and QN; however, it had an antagonist effect when used with the other combinations.
Graphical abstract16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1), steroid isolated from Solanum nudum Dunal, a Solanaceae used by folk-healers from the Colombian Pacific coast to treat malaria. It target young trophozoites and have a synergistic effect and when combined with CQ and QN.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione was isolated in vitro from Solanum nudum against target Plasmodium falciparum trophozoite stages. ► The chloroquine and quinine combination was synergistic. ► Amodiaquine, desethylamodiaquine, artemisinin and atovaquone combinations were antagonist.
