Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4371768 | Experimental Parasitology | 2008 | 5 Pages |
Abstract
The present study was undertaken to analyse the capability of HIV-1 derived TAT protein transduction domain (PTD) fused with Green Fluorescent Protein (TAT-GFP) as a delivery vehicle into a range of protozoan parasites. Successful transduction of native purified TAT-GFP was observed by fluorescent microscopy in Cryptosporidium parvum, Giardia duodenalis, and Neospora caninum. The ability to transduce peptides and other cargo into protozoan parasites, will greatly assist in the delivery of future peptide-based drugs and target validation peptides.
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Authors
Stephanie Hui Chin Lee, Ryan Jefferies, Paul Watt, Richard Hopkins, Frank Sotzik, Simon Reid, Anthony Armson, Annika Boxell, Una Ryan,