Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4371835 | Experimental Parasitology | 2008 | 10 Pages |
Abstract
SEM analysis of the flukes incubated in the presence of the drugs without haemin showed only minor and localized damage of the tegument. In the presence of haemin extensive tegumental damage, including sloughing, blebbing and eruptions, particularly in the ventral and dorsal mid-body and tail region, was evident. No difference in the extent of damage could be observed between artemether and artesunate and between the triclabendazole-resistant and non-resistant flukes. After 24Â h in vivo disruption of the tegument was evident in the artemether-treated flukes, and the damage increased in severity 48-72Â h post-treatment. Sloughing, swelling and extensive furrowing of the tegument was observed in several flukes, in particular in the tail region and the ventral apical cone region. In the artesunate treatment, tegumental damage was evident after 72Â h, but seemed slightly less pronounced when compared to the artemether-treated specimens examined at the same time point. Concluding our experiments confirm that artemether and artesunate are potent fasciocidal drugs and the tegument of adult F. hepatica appears to be a target for the action of these drugs.
Keywords
Related Topics
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Immunology and Microbiology
Parasitology
Authors
Jennifer Keiser, Gianni Morson,