SnCl2·2H2O-catalyzed efficient synthesis of β-acetamido ketones and β-acetamido ketoesters under solvent-free conditions

SnCl2·H2O has been found to be useful and highly efficient for the preparation of β-acetamido ketones and β-acetamido ketoesters by a one-pot reaction of aryl aldehydes, enolisable ketones, acetyl chloride and acetonitrile in a solvent-free media at room temperature. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times (1–2.5 h) and milder conditions.

Graphical abstractA simpler protocol has been developed for the preparation of β-acetamido ketones and β-acetamido ketoesters by a one-pot reaction using SnCl2·2H2O as a catalyst in a solvent-free media at room temperature. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times (1–2.5 h) and milder conditions. Figure optionsDownload full-size imageDownload as PowerPoint slide