Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4406355 | Saudi Journal of Biological Sciences | 2015 | 8 Pages |
Abstract
Sickle cell disease (SCD) is a hereditary blood disorder caused by a single gene. Various blood and urine biomarkers have been identified in SCD which are associated with laboratory and medical history. Biomarkers have been proven helpful in identifying different interconnected disease-causing mechanisms of SCD, including hypercoagulability, hemolysis, inflammation, oxidative stress, vasculopathy, reperfusion injury and reduced vasodilatory responses in endothelium, to name just a few. However, there exists a need to establish a panel of validated blood and urine biomarkers in SCD. This paper reviews the current contribution of biochemical markers associated with clinical manifestation and identification of sub-phenotypes in SCD.
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Authors
Ghazi A. Damanhouri, Jummanah Jarullah, Samy Marouf, S.I. Hindawi, Gohar Mushtaq, Mohammad A. Kamal,