Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4411526 | Chemosphere | 2010 | 7 Pages |
Abstract
The subacute toxicity of a commercial polybrominated diphenyl ether (PBDE) preparation, Bromkal 70-5DE, was investigated. In addition to a vehicle control, the mixture was given orally to male and female Sprague-Dawley rats for 28 d at three dose levels; 2.5, 25 and 250 mg kgâ1 b.w. dâ1. The observed effects include increased hepatic EROD activity (from 2.5 mg kgâ1 dâ1); increased liver weight (males), increased PROD activity and depletion of hepatic retinoids (from 25 mg kgâ1 dâ1); and increased liver weight (females), marked histological changes in the liver and lungs, as well as increased serum parameters such as total protein, cholesterol and albumin (from 250 mg kgâ1 dâ1). Chemical analysis of the PBDE mixture with gas chromatography/mass spectrometry (GS/MS) showed impurities of polybrominated dibenzofurans and to a lesser extent dibenzodioxins, in total levels of about 7.0 μg gâ1 of Bromkal technical mixture. The animals were thereby exposed to an estimated dose of dioxin-like equivalents corresponding to 1.3-131 ng TEQ kgâ1 b.w. dâ1. It cannot be ruled out that this level of impurities can explain the hepatic EROD induction and hepatic retinoid depletion, which are considered typical markers of toxicity mediated via the aryl hydrocarbon receptor (AhR).
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Authors
Mattias Ãberg, Emma Westerholm, Elena Fattore, Natalia Stern, Annika Hanberg, Peter Haglund, Karin Wiberg, Anders Bergendorff, Helen HÃ¥kansson,