Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4414926 | Chemosphere | 2007 | 7 Pages |
Abstract
Transformation of tamoxifen has been observed in water by prolonged sunlight irradiation. The main photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means. Photoisomerization, photocyclization and, to a lesser extent, photooxygenation appear to be involved in the degradation of the drug. The acute and chronic toxicity of the parent drug and its photoproducts were tested on non-target aquatic organisms (Brachionus calyciflorus, Thamnocephalus platyurus, Daphnia magna and Ceriodaphnia dubia). Exposure to all the compounds induced mainly chronic effects without significant differences among the parental and derivative compounds.
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Authors
Marina DellaGreca, Maria Rosaria Iesce, Marina Isidori, Angela Nardelli, Lucio Previtera, Maria Rubino,