Microwave assisted efficient synthesis of diphenyl substituted pyrazoles using PEG-600 as solvent – A green approach

•Green chemical approach.•PEG-600 as green solvent.•Piperidine mediated synthesis.•Microwave assisted reaction.•Antibacterial activities against gram positive and gram negative bacteria.

A conventional and microwave assisted efficient synthesis of diphenyl substituted pyrazole using PEG 600 as green solvent has been described. A relatively shorter reaction time with excellent yield of the piperidine mediated protocol has been attracted economically attractive and eco-friendly. All newly synthesized compounds were characterized by standard spectroscopic techniques viz., UV–visible, FT-IR, 1H-NMR and Mass spectra. The anti-microbial activities of compounds have also been tested using Minimum Inhibitory Concentration (MIC) method with two different microorganisms Staphylococcus aureus (MTCC3381) and Escherichia coli (MTCC739). The results of the antimicrobial activity revealed that the diphenyl substituted pyrazole derivatives have nice inhibiting nature against both types of bacteria of present investigation than corresponding chalcones. Since, the work has been focused on green chemical approach towards the synthesis, this protocol may be recommended for eco-friendly applications.

Graphical abstractBar Graph–I Minimum Inhibiting Concentration (MIC) (μg/ml) of the synthesized compoundsFigure optionsDownload full-size imageDownload as PowerPoint slide