Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4420339 | Ecotoxicology and Environmental Safety | 2013 | 8 Pages |
Abstract
Conversely, addition of S. perennis extract to the lead-containing medium alleviated every above syndrome. Thus, cell survival was increased and the production of reactive oxygen species caused by Pb treatment was inhibited. Taken together, our study revealed that S. perennis has potent cytoprotective effect against Pb-induced toxicity in HEK 293 cell. Such action would proceed through the decrease in ROS levels and resulting oxidative stress, which suggests a potential interest of this halophyte in the treatment of oxidative-stress related diseases.
Keywords
HEKMDASarcocornia perennisTRISPMSFNBTTBARSTCATBABHTDPPHDMEMFBSPBS1,1-diphenyl-2-picrylhydrazyl3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromideDMSODulbecco's modified Eagle's mediumMTTROSnitroblue tetrazoliumEDTAtrichloroacetic acidThiobarbituric acidOxidative stressIn vitroDimethyl sulfoxideLeadfoetal bovine serumCytotoxicityphosphate buffer salinePhenylmethanesulfonyl fluoridemalondialdehydethiobarbituric acid reactive substancesHalophytebutylated hydroxytoluenehuman embryonic kidneyReactive oxygen species
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Authors
Manel Gargouri, Christian Magné, Xavier Dauvergne, Riadh Ksouri, Abdelfattah El Feki, Marie-Agnès Giroux Metges, Hélène Talarmin,