| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4420923 | Ecotoxicology and Environmental Safety | 2012 | 10 Pages |
The present study investigated the hormones concentrations and gonads alterations of Clarias gariepinus caused by sublethel concentrations of 4-nonylphenol (0, 0.05, 0.08 and 0.1 mg/l). The changes in the activities of the hormones after exposure to these sublethel doses of 4-nonylpenol referred to endocrine disruption in Clarias gariepinus in association with histopathological changes in reproductive tissues. The levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), total thyroxine (T4), follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone concentrations significantly decreased (P<0.05) in the treated fish in comparison with control. 17-β-estradiol increased significantly (P<0.05) with 4-nonylphenol concentrations increase. Reduction in the gonadosomatic index was evident with increase of sublethal doses of 4-nonylphenol. The histopathological changes of NP-treated were recorded in gonads of Clarias gariepinus reflecting their sensitivity to NP-estrogenic like effects.
► We tested three sublethel concentrations from 4-nonylphenol on the hormonal activities of Clarias gariepinus. ► 4-nonylphenol caused hormonal disruption by increasing and decreasing hormonal activities. ► Many alterations in the reproductive organs indicating the estrogenic effect of this chemical pollutant.
