Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4422577 | Ecotoxicology and Environmental Safety | 2006 | 8 Pages |
Abstract
To test for environmental persistence in order to determine the potential of carbonic anhydrase inhibitors as larvicides, the decomposition and degradation of samples containing methazolamide (MTZ) and acetazolamide (ACZ) in aqueous solution were monitored under different conditions. Additionally, nontarget species impact was assessed in an acute toxicity test using sheepshead minnow (Cyprinodon variegatus). The fish were exposed for 120 h to 10â3 and 10â4 M each compound in replicate seawater tanks. In the high-MTZ treatment, all fish died within 48 h, while mortality in the low-MTZ treatment was 27% at 120 h. In the high-ACZ treatment mortality reached 83% at 120 h. We observed no mortality for the lowest dose of ACZ. Tissue samples were collected from the fish to investigate absorption of the compounds. In the gills, MTZ concentrations were around 40 μg gâ1 and ACZ reached concentrations up to 80 μg gâ1. Liver concentrations were low for MTZ probably due to metabolism.
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Authors
Maria del Pilar Corena, Peter van den Hurk, He Zhong, Catherine Brock, Richard Mowery, Jodie V. Johnson, Paul J. Linser,