Assessment of indirect human exposure to environmental sources of nickel: Oral exposure and risk characterization for systemic effects

This paper describes the indirect human exposure to Ni via the oral route for the regional scale in the EU, together with a method to assess additional local exposure from industrial emissions. The approach fills a gap in the generic REACH guidance which is inadequate for assessing indirect environmental exposure of metals.Estimates of regional scale Ni dietary intake were derived from Ni dietary studies performed in the EU. Typical and Reasonable Worst Case dietary Ni intakes for the general population in the EU were below the oral Derived No Effect Level (DNEL) of Ni sulfate for systemic effects. Estimates for the Ni dietary intake at the local scale take into account the influence of aerial Ni deposition and transfer from soil to crops grown near industrial plants emitting Ni. The additional dietary exposure via this local contribution was small. Despite the use of conservative parameters for these processes, this method may underestimate dietary exposure around older industrial sites because REACH guidance does not account for historical soil contamination. Nevertheless, the method developed here can also be used as a screening tool for community-based risk assessment, as it accounts for historical soil pollution.Nickel exposure via drinking water was derived from databases on Ni tap water quality. A small proportion of the EU population (< 5%) is likely to be exposed to tap water exceeding the EU standard (20 μg Ni/l). Taking into account the relative gastrointestinal absorption of Ni from water (30%) versus from solid matrices (5%), water intake constitutes, after dietary intake, the second most important pathway for oral Ni intake. Incidental ingestion of Ni from soil/dust at the regional scale, and also at the local scale, was low in comparison with dietary intake.

► Generic tools to assess indirect human exposure are inapplicable for metals. ► A review on dietary and drinking water intake of Ni in the EU is presented. ► The 95th percentile of the EU population is exposed to Ni levels below the oral DNEL for Ni sulfate. ► A method is presented to assess Ni dietary exposure near industrial plants. ► Dietary exposure is the dominant pathway for systemic Ni exposure.