Article ID Journal Published Year Pages File Type
4550680 Marine Environmental Research 2015 5 Pages PDF
Abstract

•TiO2-NPs can interact with marine contaminants modifying their toxicity.•Single exposure to n-TiO2 and CdCl2 reduces in vivo DNA stability in mussels.•n-TiO2 increases in vivo micronucleated cell frequency in Mytilus galloprovincialis.•No synergic effect is observed after co-exposure to n-TiO2/CdCl2.

Titanium dioxide nanoparticles (TiO2-NPs) continuously released into waters, may cause harmful effects to marine organisms and their potential interaction with conventional toxic contaminants represents a growing concern for biota. We investigated the genotoxic potential of nanosized titanium dioxide (n-TiO2) (100 μg L−1) alone and in combination with CdCl2 (100 μg L−1) in Mytilus galloprovincialis after 4 days of in vivo exposure. RAPD-PCR technique and Micronucleus test were used to study genotoxicity. The results showed genome template stability (GTS) being markedly reduced after single exposure to n-TiO2 and CdCl2. Otherwise, co-exposure resulted in a milder reduction of GTS. Exposure to n-TiO2 was responsible for a significant increase of micronucleated cell frequency in gill tissue, while no chromosomal damage was observed after CdCl2 exposure as well as after combined exposure to both substances.

Related Topics
Physical Sciences and Engineering Earth and Planetary Sciences Oceanography
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