Constitution of random intercept and slope model (RISM) as a special case of linear mixed models (LMMs) for repeated measurements data

In this paper, for the aim of modeling variance–covariance structure matrix of the response variables vector in random intercept and slope model (RISM) from linear mixed models (LMMs) for repeated measurements data, 13 different homogeneous and heterogeneous variance–covariance structure models are investigated comparatively in an application from a clinical trial.