Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4637730 | Journal of Computational and Applied Mathematics | 2017 | 17 Pages |
Abstract
We study a fractional order model for HIV infection where latent T helper cells are included. We compute the reproduction number of the model and study the stability of the disease free equilibrium. We observe that the reproduction number varies with the order of the fractional derivative αα. In terms of epidemics, this suggests that varying αα induces a change in the patients’ epidemic status. Moreover, we simulate the variation of relevant parameters, such as the fraction of uninfected CD4++ T cells that become latently infected, and the CTLs proliferation rate due to infected CD4++ T cells. The model produces biologically reasonable results.
Keywords
Related Topics
Physical Sciences and Engineering
Mathematics
Applied Mathematics
Authors
Carla M.A. Pinto, Ana R.M. Carvalho,