Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4753102 | Food Bioscience | 2017 | 29 Pages |
Abstract
Effect of co-administered piperine on the bioavailability of finger millet (FM) phenolic compounds was investigated in rats. FM phenolic extract was orally administered (100 mg kgâ1) to rats along with or without piperine (20 mg kgâ1). Blood, liver, intestine, kidney, and brain were analyzed for the absorbed phenolics at varying time intervals and their urinary excretion was monitored. Phenolic concentration in plasma was maximal at 8 h after oral administration of FM polyphenols (13 µg mLâ1), salicylic acid being the predominant compound. Area under the curve (AUC) for phenolic concentration in plasma significantly increased (166 μg h mLâ1 from 113) with piperine co-administration. Phenolic acids ̶ gentisic, sinapic, and ferulic acids were prominent in plasma when administered along with piperine. Phenolic concentration in liver, kidney, small intestine, and brain increased with piperine co-administration. Maximum appearance of phenolics in plasma, small intestine and kidney following the oral administration was advanced with piperine co-administration. FM-derived phenolics were found in brain at all time intervals, their concentration being higher when co-administered with piperine. Urinary phenolics excretion was higher when co-administered with piperine presumably because of higher absorption. Thus, piperine co-administration significantly increased absorption of orally administered FM phenolics and their retention in the body.
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Authors
Gavirangappa Hithamani, Krishnapura Srinivasan,