| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4760908 | Pathology | 2017 | 7 Pages |
Abstract
HER2 positive rate was 13.9% (114/820) by SD, and 12.9-16.0% using other definitions. There was higher concordance between IHC and HER2 CN by ISH than with ratio. The HER2 positive rate was significantly higher in GOJ samples than others (p = 0.03) and in endoscopic biopsies than resections (p = 0.047). In a subset of 98 positive cases, 39 (39.8%) showed heterogeneity, and in 282 endoscopic biopsies positivity rate plateaued at five tumour fragments, suggesting this is the minimum number of biopsies that should be examined.
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Authors
M. Priyanthi Kumarasinghe, Adrienne Morey, Michael Bilous, Gelareh Farshid, Glenn Francis, Guy Lampe, Glenda McCue, Vita Von Neumann-Cosel, Stephen B. Fox,