Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4761070 | Pathology | 2017 | 12 Pages |
Abstract
Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4+αβ T cells, γδ T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases. In this review, we will highlight the role of IL-17A in the pathogenesis of acute and chronic kidney diseases. Due to its pleiotropic character, IL-17A is involved in the development of atherosclerosis, hypertension, diabetic nephropathy, ischaemia-reperfusion injury, fibrosis, glomerulonephritis, nephrotic syndrome, minimal change disease and acute renal allograft rejection. In addition, inhibition of IL-17A may be a promising therapeutic target to prevent end-stage renal disease.
Keywords
MCP-1Heme oxygenase-1VCAMGM-CSFSOCS1TLRRORCDOCAIFN-γHspT helperLDLRSLEDAIWT-1ROR-γtHO-1ANCAAHRFOXP3TGF-βTNFPAFCAKICTR9SLE Disease Activity IndexASCmTORMPOI/Racute kidney injurySTATAntineutrophil cytoplasmic antibodyApoeapolipoprotein Einflammationischaemia-reperfusioninterferon-gammainterleukinInterleukin-17Akidney diseasetransforming growth factor-βregulated on activation, normal T cell expressed and secretedtumour necrosis factor-alphaToll-like receptorforkhead box P3deoxycorticosterone acetateDouble negativetumour necrosis factorGranulocyte-colony stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)G-CSFTNF-αSystemic lupus erythematosusSLEgranulocyte macrophage colony-stimulating factorSignal transducer and activator of transcriptionmajor histocompatibility complexMHCRANTESvascular cell adhesion moleculemyeloperoxidaseMechanistic target of rapamycinHenoch–Schönlein purpuraHBVhepatitis B virusmonocyte chemoattractant protein-1Keratinocyte-derived chemokinearyl hydrocarbon receptorLow-density lipoprotein receptor
Related Topics
Health Sciences
Medicine and Dentistry
Forensic Medicine
Authors
Charlotte Cortvrindt, Reinhart Speeckaert, Alena Moerman, Joris R. Delanghe, Marijn M. Speeckaert,