| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4761151 | Pathology | 2008 | 10 Pages |
Abstract
We conclude that p16INK4a immunoperoxidase shows greater specificity than sensitivity for squamous lesions; in comparison, glandular dysplasias/carcinomas show reduced specificity and sensitivity. Like all cell cycle regulatory proteins, the future diagnostic role of p16INK4a is limited. The ideal diagnostic molecular test for cervical dysplasias will detect a HR-HPV related product after, but not before, cell transformation and will reliably predict those cases yet to experience disease progression.
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Authors
Nicholas J. Mulvany, David G. Allen, Sharyn M. Wilson,