Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4761153 | Pathology | 2008 | 7 Pages |
Abstract
Characteristic breast cancer pathology is not diagnostic of a germline BRCA1 mutation, but it does indicate a pathogenic mechanism that occurs with increased frequency in BRCA1 mutation carriers. In BRCAX families, BRCA1 tumour phenotype may signal the presence of an unidentified BRCA1 mutation. However, this finding must be interpreted with regard to limits of the association between histopathology and genotype, and the importance of clinical context
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Authors
Maurice Loughrey, Pamela J. Provan, Karen Byth, kConFab Investigators kConFab Investigators, Rosemary L. Balleine,