| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4764849 | Current Opinion in Chemical Engineering | 2017 | 8 Pages |
â¢Metabolism regulates stem cell fate by altering epigenetic markers.â¢Metabolite signatures can be used to characterize differences between cell types.â¢Metabolomics can be used to identify biomarkers of developmental toxicity to drugs.â¢Metabolomics has also been used to optimize stem cell culture conditions.
Stem cells undergo extensive metabolic rewiring during reprogramming, proliferation and differentiation, and numerous studies have demonstrated a significant role of metabolism in controlling stem cell fates. Recent applications of metabolomics, the study of concentrations and fluxes of small molecules in cells, have advanced efforts to characterize and maturate stem cell fates, assess drug toxicity in stem cell tissue models, identify biomarkers, and study the effects of environment on metabolic pathways in stem cells and their progeny. Looking to the future, combining metabolomics with other -omics approaches will provide a deeper understanding of the complex regulatory mechanisms of stem cells.
