Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4767123 | Electrochimica Acta | 2017 | 7 Pages |
Abstract
Ultrasensitive determination of the chiral nature of a molecule is important for fully understanding protein and DNA structures, and for the design, synthesis and purification of drug molecules. Consequently, development of ultrasensitive detection of chiral molecules is a grand challenge and at the heart of many of today's research fields, including chemistry, biology, biotechnology and pharmacology. Here a novel method afforded by electrochemically tracing the Cu2+ ions that are replaced by L/D-carnitine on anL/D-cysteine modified gold electrode is described. The electrochemical signal of copper ionswas monitored, these were immobilized on the L/D-cysteine functionalized gold electrode surface via cooperative metal-ligand interaction, followed by replacing the Cu2+ with L-carnitine or D-carnitine chiral molecules based on the hetero- or homo- chiral interaction between carnitine and cysteine molecules. The results illustrated that the Cu2+ replacement ratio between L/D-carnitine and D/L-cysteine were higher than that between L/D-carnitine and L/D-cysteine, which is consistent with previous studies that hetero-chiral interaction is stronger than homo-chiral interaction. This study demonstrates a facile, but innovative electrochemical method to probe the chiral recognition of carnitine molecules.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Fangli Yang, Na Kong, Xavier A. Conlan, Hongbin Wang, Colin J. Barrow, Fuhua Yan, Junming Guo, Wenrong Yang,