Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4769529 | The Journal of Chemical Thermodynamics | 2017 | 30 Pages |
Abstract
Experimental ternary mutual diffusion coefficients (D11, D22, D12 and D21, obtained by the Taylor dispersion method, are reported for aqueous solutions of levodopa (L-dopa) + β-cyclodextrin (β-CD) solutions at 310.15 K and concentrations up to 0.007 mol dmâ3. Comparison of these experimental results with data predicted by a model of the diffusion that includes inclusion complexes, it is possible to conclude that the association equilibrium at 310.15 K has little effect on the diffusion properties. Support for this comes from 1H NMR spectroscopy, which shows that there are no interactions, which may be related to the reduced L-dopa/cavity interactions resulting from both the amine and carboxylate groups on L-dopa being charged.
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Authors
M.C.F. Barros, Ana C.F. Ribeiro, Miguel A. Esteso, A.J.M. Valente, M. LuÃsa Ramos, Hugh D. Burrows, Victor M.M. Lobo, Derek G. Leaist,