Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4907421 | The Journal of Chemical Thermodynamics | 2017 | 5 Pages |
Abstract
In this study, the solubility of oxcarbazepine in pure methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, acetonitrile, and tetrahydrofuran was analysed across the temperature range of 288.15-308.15Â K under atmospheric pressure by using a solid-liquid equilibrium method. The experimental values obtained data were correlated using the modified Apelblat model at each temperature. The mole fraction solubility of oxcarbazepine in all eight pure solvents increased gradually in a temperature-dependent manner. The highest mole fraction solubility of 3.08Â ÃÂ 10â3 at 308.15Â K was observed for tetrahydrofuran, followed by acetone (1.82Â ÃÂ 10â3 at 308.15Â K), acetonitrile (1.22Â ÃÂ 10â3 at 308.15Â K), methanol (1.11Â ÃÂ 10â3 at 308.15Â K), ethanol (6.17Â ÃÂ 10â4 at 308.15Â K), 1-butanol (6.17Â ÃÂ 10â4 at 308.15Â K), 1-propanol (6.16Â ÃÂ 10â4 at 308.15Â K), and 2-propanol (4.13Â ÃÂ 10â4 at 308.15Â K). The experimental solubility in all solvents correlated well with that calculated using the modified Apelblat equation across the temperature range of (288.15-308.15)Â K. Therefore, the experimental solubility and correlation equations established in this study could be useful during the crystallization/purification, pre-formulation, and formulation stages of oxcarbazepine production in laboratories and related industries.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Kyungwan Nam, Eun-Sol Ha, Jeong-Soo Kim, Do-Hoon Kuk, Dong-Hyeon Ha, Min-Soo Kim, Cheong-Weon Cho, Sung-Joo Hwang,