Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4907481 | The Journal of Chemical Thermodynamics | 2017 | 7 Pages |
Abstract
The transpiration method was used to measure the vapor pressures as a function of temperature of the following antimicrobial drugs: ciprofloxacin, enrofloxacin, norfloxacin and levofloxacin. Based on these results standard molar enthalpies, entropies and Gibbs energies of sublimation at TÂ =Â 298.15Â K were calculated and a correlation between the crystal lattice energy and the saturation vapor pressure in a number of fluoroquinolones was found. The thermophysical characteristics of the compounds studied were determined by DSC. The influence of different structural fragments of molecules substituents and the effects of hydrogen bonds in crystal lattices on the sublimation enthalpy was discussed.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Svetlana Blokhina, Angelica Sharapova, Marina Ol'khovich, German Perlovich,