Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4909300 | Journal of Saudi Chemical Society | 2017 | 11 Pages |
Abstract
A small library of compounds are synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV. Two compounds, -[(2â²,4â²-dinitrophenyl)sulphonyl]-4-(p-aminophenylsulphonylamino)-6-(2â²-chlorophenyl)-pyrimidine-5-carboxamide Fb and 2-hydrazino-4-(p-aminophenylsulphonylamino)-6-(2â²-chlorophenyl)-pyrimidine-5-carboxamide Db were found to be the most active compounds in vitro with MIC of 0.02 μg/mL against MTB and were more potent compared to isoniazid (MIC: 0.03 μg/mL).
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Nayan H. Bhuva, Pratik K. Talpara, Pankaj M. Singala, Vrajlal K. Gothaliya, Viresh H. Shah,