A convenient one-pot synthesis of novel tetraamides via 2-cyclopentylidenemalonic acid based Ugi-four component reaction

A mild and efficient Ugi four component condensation reaction was developed among aromatic aldehydes, aromatic amines, isocyanides and 2-cyclopentylidenemalonic acid to prepare a new series of N1,N3-bis((cyclohexylcarbamoyl)(phenyl)methyl)-2-cyclopentylidene-N1,N3-diphenylmalonamide derivatives. These one-pot reactions led to the construction of four amide groups with easy recovery of the desired products.