Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4909480 | Journal of Saudi Chemical Society | 2016 | 7 Pages |
Abstract
A series of novel 5-methyl-2-phenylthiazole-4-substituted-heteroazole derivatives (6-15) have been synthesized. The structures of these compounds were established by IR, 1HNMR, Mass spectral data and elemental analyses. Compounds were evaluated for their anti-inflammatory and analgesic activities as well as gastric ulcerogenic effects. Derivatives 9, 10, 14 and 15 exhibited moderate to good anti-inflammatory and analgesic activities in carrageenan-induced rat paw edema and acetic acid-induced writhing in mice respectively, with low ulcerogenicity compared with the standard drug diclofenac sodium.
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Authors
S.N. Thore, Sunil V. Gupta, Kamalkishor G. Baheti,