Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4909542 | Journal of Saudi Chemical Society | 2016 | 8 Pages |
Abstract
A novel series of 2-[5-(4-substituted phenyl)furan-2-yl]-4,5-diphenyl-1H-imidazole derivatives (2a-c) were synthesized and characterized using IR, 1H NMR and GC-MS spectra. These compounds were in vitro screened against several bacterial species as well as Candida albicans, the common fungi species and found exhibiting moderate to potent activity. Docking of synthesized compounds against glucosamine-6-phosphate synthase, the target enzyme for the antimicrobial agents, was achieved to explore and explain the interactions of the discovered hits within the amino acid residues of the enzyme binding pocket. The docking results enhanced the activity of new derivatives as promising antimicrobial agents.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Ivan H.R. Tomi, Ali H.R. Al-Daraji, Ahmed Mutanabbi Abdula, Mohammed F. Al-Marjani,