High-turnover aminopyridine-based Pd-catalysts for Suzuki–Miyaura reaction in aqueous media

•The first time report of PdCl2–aminopyridine catalysts for Suzuki–Miyaura reaction•The new catalysts are high-turnover, active, stable in air and aqueous media.•The catalysts show excellent tolerance to a wide range of sensitive functional groups.•High to excellent isolated yields are achieved in most cases without chromatography.

A high-turnover catalytic system based on commercially available aminopyridines (L) and PdCl2 has been developed for Suzuki–Miyaura reaction in aqueous media. Reactions of arylboronic acids with a wide range of aryl iodides, bromides and chlorides proceeded in the presence of these catalysts for a short time in aqueous media to afford the cross-coupling products in high yields. Furthermore, this protocol allows tolerating a wide range of functional groups.

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