Co-occurrence and symptomatology of fatigue and depression

Fatigue and depression are highly correlated traits within the community. Depression symptomatology and prevalence are significantly increased in fatigued individuals. Fatigue and especially the symptoms of insomnia and poor concentration are strong predictors of depression. Notably, the association between fatigue and depression is independent of their overlapping symptomatology. Therefore, presentation with fatigue, and in particular the symptoms of insomnia and poor concentration, should be considered as warning signs of depression in older adults.