| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4930514 | European Neuropsychopharmacology | 2017 | 5 Pages |
Abstract
Telomere length attrition has been demonstrated in schizophrenia but not in individuals in ultra high risk (UHR) for psychosis. The present study aimed to compare the leukocyte telomere length (TL) between patients at UHR for psychosis and healthy controls (HC). Twenty-two participants with UHR and 88 HC were enrolled in this study. Telomere lengths were determined using a multiplex qPCR assay. After adjustment for age, sex, ethnicity, and education, patients in UHR, compared with HC groups, had shorter telomere length (RR: 0.929, p=0.031). Shorter leukocyte telomere length in UHR could represent early signs of accelerated aging in this population.
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Authors
Pawan Kumar Maurya, Lucas Bortolotto Rizzo, Gabriela Xavier, Priscila Farias Tempaku, Maiara Zeni-Graiff, Marcos L. Santoro, Diego Robles Mazzotti, André Zugman, Pedro Pan, Cristiano Noto, Michael Maes, Elson Asevedo, Rodrigo B. Mansur,