Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4931467 | Journal of the American Academy of Child & Adolescent Psychiatry | 2016 | 8 Pages |
Abstract
This study provides new evidence of a neural signature of vulnerability to anxiety disorders. By investigating both anticipation and response to images, we identified that high-risk, inhibited children have widespread alterations in PFC function and connectivity, characterized by an inability to proactively prepare for social threat combined with heightened reactivity to social stimuli. Thus, children at high risk for anxiety show significantly altered prefrontal cortical function and connectivity before the onset of anxiety disorders.
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Authors
Jacqueline Alexandra MD, PhD, Margaret M. MD, Uma MD, Jennifer Urbano PhD,