Article ID Journal Published Year Pages File Type
4931467 Journal of the American Academy of Child & Adolescent Psychiatry 2016 8 Pages PDF
Abstract
This study provides new evidence of a neural signature of vulnerability to anxiety disorders. By investigating both anticipation and response to images, we identified that high-risk, inhibited children have widespread alterations in PFC function and connectivity, characterized by an inability to proactively prepare for social threat combined with heightened reactivity to social stimuli. Thus, children at high risk for anxiety show significantly altered prefrontal cortical function and connectivity before the onset of anxiety disorders.
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Authors
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