Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4932822 | Neurobiology of Aging | 2017 | 9 Pages |
Abstract
In this study, we examined the 24-hour plasma melatonin patterns of young adult (â¼11Â years of age) and old (â¼24Â years of age) rhesus macaques, and determined how they would be influenced by 30% caloric restriction (CR). Well-defined 24-hour plasma melatonin rhythms were observed in all the males but only the old animals showed significant attenuation of night-time melatonin levels. Moreover, 4.5Â years of CR failed to prevent the age-associated decline in plasma melatonin levels in the old males and caused a significant decrease in the young adult males. Similar plasma melatonin rhythms were also observed in all the females but no age-related decline was detected, and 2Â years of CR had no obvious effect on plasma melatonin levels. If anything, there was a trend for the CR to decrease melatonin levels in the young adult females. Taken together, the results fail to show any clear benefit of CR on plasma melatonin levels in old rhesus macaques and may even be detrimental to plasma melatonin levels in young adults.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Nona Aghazadeh-Sanai, Jodi L. Downs, Julie A. Mattison, Donald K. Ingram, Steven G. Kohama, Henryk F. Urbanski,