Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4934189 | Psychoneuroendocrinology | 2017 | 8 Pages |
Abstract
In conclusion, the results suggest that DLK2 plays an important role in the regulation of emotional behaviors and relevant targets of the stress axis, NOTCH pathway and GABAergic neurotransmission. In addition, the deletion of Dlk2 blocked the anxiolytic response to alprazolam. Future studies are needed to determine the relevance of DLK2 as a potential therapeutic target for the treatment of neuropsychiatric disorders with anxiety or depressive-like behaviors.
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Authors
Francisco Navarrete, MarÃa S. GarcÃa-Gutiérrez, Jorge Laborda, Jorge Manzanares,