Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4934391 | Psychoneuroendocrinology | 2017 | 21 Pages |
Abstract
Suicide attempters had higher insulin- and lower glucagon-levels in plasma- and CSF compared to controls. Except for P-glucagon these associations remained significant after adjusting for age and/or BMI. Patients reported significantly more expressed interpersonal violence compared to healthy volunteers. Expressed violence was significantly positively correlated with P- and CSF-insulin and showed a significant negative correlation with P-glucagon in study participants. These findings confirm and extend prior reports that higher insulin and lower glucagon levels in plasma and cerebrospinal fluid are associated with suicidal behavior pointing towards a potential autonomic dysregulation in the control of insulin and glucagon secretion in suicidal patients.
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Authors
Marie Bendix, Kerstin Uvnäs-Moberg, Maria Petersson, Viktor Kaldo, Marie Ã
sberg, Jussi Jokinen,