| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4934407 | Psychoneuroendocrinology | 2017 | 36 Pages |
Abstract
Post-anesthesia stressors may exacerbate/unmask neurodevelopmental abnormalities even after a relatively short anesthetic with etomidate, leading to dysregulated stress response systems and neurobehavioral deficiencies in adulthood. Amelioration by bumetanide suggests a mechanistic role for etomidate-enhanced gamma-aminobutyric acid type A receptor-mediated depolarization in initiating long-lasting alterations in gene expression that are further potentiated by subsequent maternal separation.
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Authors
Ling-Sha Ju, Jiao-Jiao Yang, Nikolaus Gravenstein, Christoph N. Seubert, Timothy E. Morey, Colin Sumners, Terrie Vasilopoulos, Jian-Jun Yang, Anatoly E. Martynyuk,