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Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy

Article ID Journal Published Year Pages File Type
4935324 Seizure 2017 21 Pages PDF
Abstract
These results suggested that ABCB1 rs1045642 and UGT2B7 rs7439366 may affect OXC pharmacokinetics and therapeutic efficacy in Han Chinese patients with epilepsy. However, further studies in larger populations and other ethnic groups are required.
Keywords
ABCB1ABCC2HNF4αUGT2B7OxcarbazepinePharmacogenetics
Related Topics
Life Sciences Neuroscience Behavioral Neuroscience
Preview
Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy
Authors
Chunhong Shen, Bijun Zhang, Zhirong Liu, Yelei Tang, Yinxi Zhang, Shan Wang, Yi Guo, Yao Ding, Shuang Wang, Meiping Ding,
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Journal
Seizure
Journal: Seizure
Related Categories
ABCB1
ABCC2
HNF4α
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